2012•Journal of Huaqiao UniversityRequires access

Study of the Drug-Loading Property of Heparin-Loading ACA Microcapsules

Shi‐Bin Wang

Abstract

Calcium alginate microspheres with mean diameter 820 nm and calcium alginate/chitosan microcapsules were prepared by emulsion-curing.Using heparin as a model drug,the effects of the swelling condition,the different concentrations of heparin,the drug-loading condition,chitosan molecular weight,the membrane forming time,the different concentrations of chitosan and different modified chitosans on drug-loading were investigated.Results indicated that the maximum drug-loading was 77.4%.

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Key concepts: Chitosan, Swelling, Drug, Emulsion, Heparin, Calcium, Curing (chemistry), Drug delivery