2010•Huagong jinzhanRequires access

Properties of calcium alginate/chitosan microcapsules with high drug-loading

Qi Lan

Abstract

Calcium alginate microspheres with mean diameter of 820 nm and calcium alginate/chitosan microcapsules were prepared by emulsion-curing.Effects of drug concentration,the molecular weight and concentration of chitosan on drug-loading and drug-release of the microcapsules were investigated using bovine serum albumin(BSA)as a model drug.The maximum drug-loading was over 40%,and the microcapsules also showed good property of sustained-release in vitro.

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Key concepts: Chitosan, Drug, Calcium, Emulsion, Chemistry, Drug delivery, Calcium alginate, Curing (chemistry)