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2009•Chinese Journal of Bone and Joint InjuryRequires access

A Rat Model of Disc Herniation Spontaneous Resorption

Tcm Jiangsu

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Abstract

Objective To investigate the histopathological changes of sequestration-type herniated disc,and the related factors of its absorption.Methods Twenty male Sprague-dawley(SD) rats were chosen.The rats were divided into control group and experimental group at random.In the experimental group,discs were harvested from the caudal vertebrae and placed subcutaneously in the epidural.After 30 days,the rats were killed and discs were harvested.HE staining and immunohistochemistry were used for analysis of cells and tissue.In the control group,coil was placed subcutaneously in the epidural.Results Compared with the control group,quality and shape displayed significant decrease in the experimental group.The TNF-ɑ and VEGF pulposus were observed in experimental group with immunohistochemisty.Conclusion The extent of spontaneous absorption mainly depends on the origin of the sequestration tissue.The VEGF and TNFɑ play important roles in the absorption process.

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What this paper is about

Objective To investigate the histopathological changes of sequestration-type herniated disc,and the related factors of its absorption.Methods Twenty male Sprague-dawley(SD) rats were chosen.The rats were divided into control group and experimental group at random.In the experimental group,discs were harvested from the caudal vertebrae and placed subcutaneously in the epidural.After 30 days,the rats were killed and discs were harvested.HE staining and immunohistochemistry were used for analysis of cells and tissue.In the control group,coil was placed subcutaneously in the epidural.Results Compared with the control group,quality and shape displayed significant decrease in the experimental group.The TNF-ɑ and VEGF pulposus were observed in experimental group with immunohistochemisty.Conclusion The extent of spontaneous absorption mainly depends on the origin of the sequestration tissue.The VEGF and TNFɑ play important roles in the absorption process.

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Available abstract

Objective To investigate the histopathological changes of sequestration-type herniated disc,and the related factors of its absorption.Methods Twenty male Sprague-dawley(SD) rats were chosen.The rats were divided into control group and experimental group at random.In the experimental group,discs were harvested from the caudal vertebrae and placed subcutaneously in the epidural.After 30 days,the rats were killed and discs were harvested.HE staining and immunohistochemistry were used for analysis of cells and tissue.In the control group,coil was placed subcutaneously in the epidural.Results Compared with the control group,quality and shape displayed significant decrease in the experimental group.The TNF-ɑ and VEGF pulposus were observed in experimental group with immunohistochemisty.Conclusion The extent of spontaneous absorption mainly depends on the origin of the sequestration tissue.The VEGF and TNFɑ play important roles in the absorption process.

Key concepts: Medicine, Resorption, Immunohistochemistry, Rat model, VEGF receptors, Disc herniation, Absorption (acoustics), Pathology

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