The influence of TNF-α inhibitor in the spontaneous resorption of ruptured lumbar disc herniation: An experimental study

Objective To investigate the influence of TNF-α inhibitor(Etanercept)in the spontaneous resorption of ruptured lumbar disc herniation.Methods forty-two male SD rats after two weeks of feeding adaptation were randomly divided into drug group and non-drug group.non-drug group were randomly divided into model group Ⅰ(Disc not puncture group)、model group Ⅱ(Disc puncture group);drug group:(TNF-α inhibitor group)injected with etanercept.All animal were sacrificed after the success of animal model after administration for 4weeks.Intervertebral discs in rats made to do TNF-α immunohistochemistry and detected the loss of cell content of macrophages.Results Disc punctured group TNF-α expression by immunohistochemical staining high rate,while disc not puncture group positive rate less,TNF-α inhibitor group have little positive expression;All group has a positive expression of macrophage,but disc puncture group,macrophages positive expression was the highest.Conclusion Ruptured lumbar disc herniation is easily resorption.However,TNF-α inhibitor reduce the inflammatory response within the herniated disc level,is not conducive to the removal of necrotic tissue and resorption.