The protective effect of Yinchen Hexue capsule on immunological liver injury in mice

Objective To investigate the protective effect of the Yinchen Hexue capsule on the BCG and LPS-induced immunological liver injury in mice.Methods Kunming mice were divided into control group,model group,lowdosage,intermediate-dosage and high-dosage Yinchen Hexue capsule groups.On the first day,the model group and the protection groups were injected BCG from tailveil and then the protection groups were administered with Yinchen Hexue capsule by gastric perfusion 30,60,120mg·kg-1.At the end of 12 days,2 hr after gavage,the model group,high-dosage and intermediate-dose Yinchen Hexue capsule groups were injected with LPS via the tail vein.12h later,mice were weighed.The serum ALT and AST activity were determined and the mice were killed to calcu-late liver somatic index and spleen index.Liver homogenate were prepared and liver tissue MDA,GSH content and SOD and GSH-Pxactivity were tested.Results The Yinchen Hexue capsule groups reduced the somatic index,spleen index and decreased serum ALT,AST activity of mouse liver,compared with the model group(p 0.05)and also decreased MDA content,increased GSH content and GSH-Px activity,compared with the model group(p 0.05).Conclusion Yinchen Hexue capsule protected the BCG and LPS-induced immunological liver injury in mice.