Expression of MDM2 and p53 in Ovarian Epithelial Tumors

To investigate the role of MDM2 and p53 in the pathogenesis and development of ovarian epithelial tumors. With immunohistochemistry,the expressions of p53 and MDM2 were observed in 8 cases with ovarian benign epithelial tumors,7 cases with border_ line epithelial tumors and 19 cases with malignant epithelial tumors. In ovarian benign epithelial tumors,borderline epithelial tumors and malignant epithelial tumors,the positive rates of MDM2 and p53 were 12.50% (1/8),28.59% (2/7) ,47.37% (9/19);and 25.00% (2/8), 57.14% (4/7), 78.95% (15/19),respectively.The positive detection of MDM2 between the three groups of ovarian tumors was not significantly different (P0.05),but the expression of p53 in malignant epithelial tumors was significantly higher than those in the other groups (P0.05).In the malignant epithelial tumors,there was no significant association between p53 and MDM2 expression (P0.05).[Conclusions] The expression of p53 correlates with the malignant phenotypes of ovarian epithelial tumors.In the pathogenesis and development of malignant ovarian epithelial tumors,the abnormal expression of p53 may be more significant than that of MDM2.