A study on expression of p73 protein in epithelial ovarian neoplasms.

Objective:To study the expression of p73 protein and to analyze their roles in epithelial ovarian tumors.Methods:The expression of p73 protein in 15 cases of benign ovarian tumor,12 cases of borderline ovarian tumor,50 cases of ovarian carcinomawas and 15 cases of normal ovarian tissues were analyzed by immunohistochemical technique.Results:The Expression of p73 protein was 26.7%(2/15)in benign ovarian tumors,50%(6/12) positive in borderline tumors,13.3%(1/15) in normal tissue and 76%(38/50) in ovarian epithelial malignant tumors.There was obvious difference in the expression of p73 between malignant and borderline tumors,the same result appeared in the group of malignant tumors and normal tissue(P0.05).In the malignant tumor group had no relation to borderline ovarian tumor(P0.05).The Expression of p73 protein had a relationship with the Neoplasms type: phlegm tumors′ p73 protein had a high expression in the nucleolus,while the serosity tumors in the cell plasma.Conclusion:p73 Gene takes part in the development of malignant epithelial ovarian tumors with high expression.The type of mutant p53 gene may be used as an indicator of judging benign and malignant tumors in epithelial ovarian tumors.The type of p73 Gene expression has a correlation with the type of neoplasms.