Protective effect of bFGF on learning and memory impairment in Vascular Dementia Mice

Objective To investigate the protective effect of basic fibroblast growth factor on learning-memory disorder in mice with vascular dementia and its mechanism.Methods Eighty healthy Kunming mice were divided randomly into 4 groups:control group,sham-operated group,model group and bFGF intervention group.Using repeated cerebral ischemia-reperfusion in conscious mice to establish the VD model.Infulence of bFGF on behavior were studied by Morris water maze.The change of levels of SOD(superoxide dismutase)and MDA(malondialdehyde)was analyzed with biochemistrical analysis method.Results In compared with the mice in model group,the protective effect of basic fibroblast growth factor on learning-memory disorder was improved significantly,the activity of SOD was remarkably inceased(P0.01),MDA content was markedly reduced(P0.01).Conclusion Basic fibroblast growth factor can improve learning-memory disorder in mice with vascular dementia.Its mechanism may be related to improve the metabolism of free radicals and lipid peroxidation.