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Expression and significance of cyclooxygenase-2 in CIN and cervical cancer

Ling Wen

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Abstract

Objective:To detect the expression of cyclooxygenase-2(cox-2) in cervical intraepithelial neoplasia(CIN) and primany cervical cancer and to evaluate whether it could provide clinical significant informations.Methods:The expression of cox-2 was studied by immunohistochemical Strep-Aviodin-Biotin-enzyme-Complex method(S-ABC) in 16 cases of primany cervical cancer,39 cases of CIN and 8 cases of normal cervical tissue.Results:The positive rate in the CIN and cervical carcinoma was higher than normal cervical tissues(P0.05).The level of Cox-2 was higher in cancer samples compared respectively with cervical intraepithelial neoplasias(P0.05).The level of Cox-2 was higher in both CINⅡ and CINⅢ compared respectively with CINⅠ(P0.05).There was no significant difference of Cox-2 between CINⅡand CINⅢ(P0.05).Conclusion:The expression of Cox-2 is related to the generation of cervical cancer,and it plays an importment role in the generation and development of CIN.

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What this paper is about

Objective:To detect the expression of cyclooxygenase-2(cox-2) in cervical intraepithelial neoplasia(CIN) and primany cervical cancer and to evaluate whether it could provide clinical significant informations.Methods:The expression of cox-2 was studied by immunohistochemical Strep-Aviodin-Biotin-enzyme-Complex method(S-ABC) in 16 cases of primany cervical cancer,39 cases of CIN and 8 cases of normal cervical tissue.Results:The positive rate in the CIN and cervical carcinoma was higher than normal cervical tissues(P0.05).The level of Cox-2 was higher in cancer samples compared respectively with cervical intraepithelial neoplasias(P0.05).The level of Cox-2 was higher in both CINⅡ and CINⅢ compared respectively with CINⅠ(P0.05).There was no significant difference of Cox-2 between CINⅡand CINⅢ(P0.05).Conclusion:The expression of Cox-2 is related to the generation of cervical cancer,and it plays an importment role in the generation and development of CIN.

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Available abstract

Objective:To detect the expression of cyclooxygenase-2(cox-2) in cervical intraepithelial neoplasia(CIN) and primany cervical cancer and to evaluate whether it could provide clinical significant informations.Methods:The expression of cox-2 was studied by immunohistochemical Strep-Aviodin-Biotin-enzyme-Complex method(S-ABC) in 16 cases of primany cervical cancer,39 cases of CIN and 8 cases of normal cervical tissue.Results:The positive rate in the CIN and cervical carcinoma was higher than normal cervical tissues(P0.05).The level of Cox-2 was higher in cancer samples compared respectively with cervical intraepithelial neoplasias(P0.05).The level of Cox-2 was higher in both CINⅡ and CINⅢ compared respectively with CINⅠ(P0.05).There was no significant difference of Cox-2 between CINⅡand CINⅢ(P0.05).Conclusion:The expression of Cox-2 is related to the generation of cervical cancer,and it plays an importment role in the generation and development of CIN.

Key concepts: Medicine, Cervical intraepithelial neoplasia, Cervical cancer, Immunohistochemistry, Cyclooxygenase, Cervical carcinoma, Clinical significance, Cancer

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