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Expression and Significance of HIF-1α in Non Small Cell Lung Cancer Tissues

Jiang Yun-sheng

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Abstract

Objective To investigate the relationship between the HIF-1α expression and tumor biological characteristics in non small cell lung cancer(NSCLC). Methods The expression of HIF-1α in NSCLC tissues was evaluated by immunohistochemical method. Results The positive rate of HIF-1α expression in NSCLC was 71.11%, and significantly higher than that in normal lung tissues(P0.005). There was a significant correlation between HIF-1α expression and tumor lymph node metastasis, and TNM stages, but no significant correlation was found between HIF-1α expression and tumor size, pathological grade, and tumor pathological type. Conclusion The results suggested that the expression of HIF-1α correlates closely with the metastasis and invasion of NSCLC.

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What this paper is about

Objective To investigate the relationship between the HIF-1α expression and tumor biological characteristics in non small cell lung cancer(NSCLC). Methods The expression of HIF-1α in NSCLC tissues was evaluated by immunohistochemical method. Results The positive rate of HIF-1α expression in NSCLC was 71.11%, and significantly higher than that in normal lung tissues(P0.005). There was a significant correlation between HIF-1α expression and tumor lymph node metastasis, and TNM stages, but no significant correlation was found between HIF-1α expression and tumor size, pathological grade, and tumor pathological type. Conclusion The results suggested that the expression of HIF-1α correlates closely with the metastasis and invasion of NSCLC.

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Available abstract

Objective To investigate the relationship between the HIF-1α expression and tumor biological characteristics in non small cell lung cancer(NSCLC). Methods The expression of HIF-1α in NSCLC tissues was evaluated by immunohistochemical method. Results The positive rate of HIF-1α expression in NSCLC was 71.11%, and significantly higher than that in normal lung tissues(P0.005). There was a significant correlation between HIF-1α expression and tumor lymph node metastasis, and TNM stages, but no significant correlation was found between HIF-1α expression and tumor size, pathological grade, and tumor pathological type. Conclusion The results suggested that the expression of HIF-1α correlates closely with the metastasis and invasion of NSCLC.

Key concepts: Immunohistochemistry, Pathological, Lung cancer, Pathology, Lymph node metastasis, Metastasis, Lung, Medicine

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