DRUG TOLERANT ANLERANT OF 263 STRAINS ESCHERICHIA COLI

Objective:To understand drug tolerance of escherichina coli in common antibacterial drugs and the difference of drug tolerance in different samples,and to select drugs for clinical reference.Methods:WT263 clinical separate strains escherichia coli and drug tolerance in our hospital from Jan 2002 to July 2004 were identified and detected.Drug sensitive experiment was performed by (K-B) method ,distinguished standard according to NCCLS 2000.Results:WTDrug tolerant rate of escherichia coli in cefoperazone/sulbactam and imipenem were 2.3% and 0.In cephaloglycin,cephalexin,Cephamycin,aztreonam,amikacin,nitrofurantoin and piperacillim were 8.7%-21.3%; In penicillins,Quinovic-ketone sulfonamides were 61.6%-83.3%; Drug tolerant rate of escherichia coli in sputum was higher than in blood,urine and other samples separate strains.Conclusion:Escherichia coli has a higher drug tolerant rate in penicillins,quinovic-ketone,sulfonamides but lower in cephaloglycin cephalexin,cephamycin,aztreonam,Amikacin,Nitrofurantoin and piperacillin.At present,It is sensitive to imipenem and cefoperazone/suibactam;The drug tolerant rate exists difference in different samples in same antibacteral drugs.