Drug resistance of Escherichia coliand its production of extended spectrum β-lactamases

OBJECTIVE To explore the drug resistance of Escherichia coli and the production of extended-spectrum β-lactamases so as to provide basis for the clinical reasonable use of antibiotics.METHODS A retrospective study was carried out to investigate the relevant data of the isolated E.coli from Jan 2010 to Dec 2011.RESULTS Totally 1043 E.coli isolates were mainly isolated from urine.The detection rates of ESBLs-producing E.coli in 2010 and 2011 were respectively 52.9% and 51.18%,the difference between the ESBLs-producing strains and non-ESBLs-producing strains was not statistically significant.The drug resistance rate of E.coli was 0 to imipenem,the drug resistance rate to piperacillin/tazobactam varied between 7.29% and 6.69%,ampicillin/sulbactam ranging from 38.56% to 34.84%,ampicillin and cefazolin higher than 87.0%.The drug resistance rate to aztreonam,ceftriaxone,sulfamethoxazole/trimethoprim,cefotrximl,ciprofloxacin,and levofloxacin varied as high as from 60.00% to 77.00%.CONCLUSION E.coli is highly resistant to the most antibacterial agents.The rational use of antibacterial agents should be strengthened so as to achieve a good treatment effect.