ANALYSIS OF THE DRUG RESISTANCE OF THE CLINICAL ISOLATED ESCHERICHI COLI

[Objective]To understand drug tolerance of escherichina coli in common antibiotic and the difference of drug tolerance in different samples,and to select drugs for clinical reference.[Methods]395 clinical separate strains escherichia coli and drug tolerance in our hospital from Jan2007 to July 2009 were identified and detected. Drug sensitive experiment was performed by(K- B)method,distinguished standard according to NCCLS 2006.[Results]Drug tolerant rate of escherichia coli in cefoperazone/sulbactam and imipenem were 2.5% and 0,respectively. The rates of cephaloglycin,cephalexin,Cephamycin,aztreonam,amikacin,nitrofurantoin and piperacillim were at the range of 9.1%-21.5%;The rates of penicillins,Quinovic-ketone sulfonamides were at the range of 62.0%-83.5%;Drug tolerant rate of escherichia coli in sputum was higher than that in blood,urine and other samples separate strains.[Conclusion]Escherichia coli has a higher drug tolerant rate in penicillins,quinovic-ketone,sulfonamides but lower in cephaloglycin cephalexin,cephamycin,aztreonam,Amikacin,Nitrofurantoin and piperacillin. At present,it is sensitive to imipenem and cefoperazone/suibactam;The drug tolerant rate exists difference in different samples in same antibiotic.