Analysis on results of cervical liquid-based cytology in 11030 cases

Objective:To explore the value of thin layer cytology test(TLT) plus cervical liquid-based cytology in gynecological screening. Methods:The results of cervical liquid-based cytology in 11 030 patients from December 2006 to June 2009 were analyzed,all the patients were given TBS reports;711 positive patients received histological biopsy,the results of cervical liquid-based cytology and histological biopsy were compared. Results:Among 11 030 patients receiving cervical liquid-based cytology,757 patients were diagnosed as above-ASCUS pathological changes,the positive detection rate was 6.86%.Among 711 positive patients,165 patients were found with LSIL,96 patients were diagnosed as condyloma and cervical intraepithelial neoplasia(CIN),the accordance rate was 58.18%;43 patients were found with excessive diagnosis(inflammation),accounting for 26.06%;26 patients were found with under-diagnosis(CIN Ⅱ and CIN Ⅲ)(15.76%).Among 49 patients with HSIL,25 patients were diagnosed as CIN Ⅱ and CIN Ⅲ,the accordance rate was 51.02%;23 patients were found with excessive diagnosis,accounting for 45.10%(3 patients with inflammation,2 patients with condyloma and 18 patients with CIN Ι),one patient was found with under-diagnosis(squamous cell carcinoma);among 497 patients with ASC-US,ASC-H and AGC-NOS,114 patients were diagnosed as condyloma and CIN,the detection rate was 22.94%. Conclusion:TLT plus cervical liquid-based cytology is an effective screening method of cervical precancerous lesion,but it has false negative and positive results,the cases with abnormal results of cervical liquid-based cytology should be confirmed furtherly by biopsy.