The value of thin liquid-based cytology test in cervical lesions screeing:a study of 10 272 cases

Objective To study the clinical characteristics of cervical lesions and value of thin liquid-based cytology test (TCT) in screening of cervical lesions.Methods Eligible 10 272 subjects underwent TCT were from in-and out-patient department from April 2007 to April 2009.The cases of atypical squamous cell (ASC) and above were detected by colposcopy,and biopsy sampling taken.High risk type human papillomavirus (HPV) 16/18 was detected on tissue section by immunohistochemical method.Results Of 10 272 cases,1 172 were ASC and above,including 534 ASC,12 atypical glandular cell (AGC),242 low grade squamous intraepithelial lesions (LSIL),338 high grade squamous intraepithelial lesions (HSIL) and 46 cervical carcinoma.By pathological examination,309 cases were diagnosed as cervical intraepithelial neoplasia (CIN)1,151 CIN2,277 CIN3 and 112 cervical cancer.The coincidence rates of TCT and pathologic histology were 30.99%(75/242)in LSIL,65.38%(221/338) in HSIL and 82.61%(38/46) in cervical carcinoma,respectively. The ages of high prevalence of CIN were 31-40 years and 41-50 years next;the ages of high prevalence of cervical carcinoma were 41-50 years and 31-40 years next. Of 10 272 cases,4 491 were cervical erosions and 426 with CIN;503 were trichomonas infection and 57 with CIN; 693 were fungal infection and 72 with CIN;944 cases presented positive HPV16/18 and 670 with CIN.Conclusions Cervical lesions have a younger tend.The incidence of CIN in patients with HPV infection is significantly higher than those of cervical erosions,trichomonas infection and fungal infection.HPV infection is obviously correlated with cervical lesions.To decrease infection of HPV,cure and stop progression of CIN are the key links for decreasing incidence of cervical carcinoma.