2007•Zhongguo redai yixueRequires access
Toxicological assessment of safety of Longgui wine.
Zheng DingXian
Open publisher page 0 citations
Abstract
Objective To study the safety of Longgui wine. Methods Acute toxicity test in mice, Micronucleus test of bone marrow cell, sperm shape abnormality test, Ames test and thirty days feeding test were conducted. Results The oral MTD in mice was over 20.0g/kg.bw and no genotoxicity was identified in micronucleus test of bone marrow cell, sperm shape abnormality test or Ames test. In thirty days test, there were no significant differences observed in body weight, food availability, hematologic and biochemical indices as well as in the ratio of organ to body of rats between various dose groups and control group. In addition, there were no apparent changes in morphology and histopathology discovered in the main organs. Conclusion Longgui wine is safe.