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2004•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Toxicological study on Sipunculidae Capsule

Jiang Ding, Obio Marine

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Abstract

Aim To estimate the toxicological characterization of Sipunculidae Capsule.Methods The acute toxicity test,micronucleus test of bone marrow cell,sperm shape abnormality test in mice,the Ames test,and 30 days feeding test in rat were studied.Results (1)The acute toxicity test showed that the LD 50 of Sipunculidae Capsule was more than 10.0g·kg -1 .(2)The results of Ames test,micronucleus test of bone marrow cell,and sperm shape abnormality test were negative.(3)The 30 days feeding test showed that the Sipunculidae Capsule have no cumulative toxicity in mice.Conclusion The results showed that the Sipunculidae Capsule have no toxicity,and it can’t cause mutation and heredity toxicity.

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What this paper is about

Aim To estimate the toxicological characterization of Sipunculidae Capsule.Methods The acute toxicity test,micronucleus test of bone marrow cell,sperm shape abnormality test in mice,the Ames test,and 30 days feeding test in rat were studied.Results (1)The acute toxicity test showed that the LD 50 of Sipunculidae Capsule was more than 10.0g·kg -1 .(2)The results of Ames test,micronucleus test of bone marrow cell,and sperm shape abnormality test were negative.(3)The 30 days feeding test showed that the Sipunculidae Capsule have no cumulative toxicity in mice.Conclusion The results showed that the Sipunculidae Capsule have no toxicity,and it can’t cause mutation and heredity toxicity.

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Available abstract

Aim To estimate the toxicological characterization of Sipunculidae Capsule.Methods The acute toxicity test,micronucleus test of bone marrow cell,sperm shape abnormality test in mice,the Ames test,and 30 days feeding test in rat were studied.Results (1)The acute toxicity test showed that the LD 50 of Sipunculidae Capsule was more than 10.0g·kg -1 .(2)The results of Ames test,micronucleus test of bone marrow cell,and sperm shape abnormality test were negative.(3)The 30 days feeding test showed that the Sipunculidae Capsule have no cumulative toxicity in mice.Conclusion The results showed that the Sipunculidae Capsule have no toxicity,and it can’t cause mutation and heredity toxicity.

Key concepts: Ames test, Toxicity, Capsule, Micronucleus test, Sperm, Acute toxicity, Bone marrow, Biology

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