The relationship between liver pathologic histology and levels of serum HBV-DNA,ALT in patients with chronic hepatitis B

Objective:To investigate the relationship between serum HBV DNA levels,aminotransferase and grading and staging of liver tissues in patients with chronic hepatitis B.Methods:Routine biochemical liver function tests and serum HBV DNA level was assayed by amplisensor quantitative polymerase chain reaction in 285 patients;and the liver biopsy was performed and the grading and staging of the liver were routinely obtained.Results:There was not obvious correlation between serum HBV DNA level and the grading and staging.A significant inverse relationship between the HBV DNA and hepatitis activity was demonstrated in 230 patients with positive HBeAg.The serum ALT level was consistent with hepatitis activity.Conclusion:There is no significant correlation between serum HBV DNA and grading and staging.In HBeAg-positive patients,serum HBV DNA levels showed a significant negative correlation with hepatic activity index.The higher ALT in serum shows the more severe hepatitis activity,and ALT could be helpful for assessing the hepatitis activity.