Study of the distribution and antimicrobial resistance of Klebsiella pneumoniae in the Guangzhou area

Objective To investigate the distribution and antimicrobial resistance of Klebsiella pneumoniae in the Guangzhou area and provide clinical guidelines for the rational use of antimicrobial agents. Methods 1 556 strains of Klebsiella pneumoniae were isolated from 1999 to 2004 in the Guangzhou area and the antibacterial susceptibility testing for these isolates was performed by disk diffusion method. The results were analyzed by the WHONET 5.3 computer program. Results 718( 46.1% ) strains were isolated from sputum, 261 (16.8% ) from urine, and 164 (10.5% ) from blood samples, respectively. Imipenem was the most sensitive antimicrobial agent against Klebsiella pneumoniae infection, followed by cefepime. The prevalence of extended- spectrum beta- lactamaese was 41.3% ～ 44.7% . The multi- drug resistance rate of Klebsiella pneumoniae from urine samples was significantly higher than that from other samples. Conclusions The clinical isolates of Klebsiella pneumoniae have a higher drug resistance in the Guangzhou area. It is urgent to have antibiotics used reasonably.