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2008•Chinese Journal of Modern Drug ApplicationRequires access

Qptimized research in prescription to slowrdease tablets of Gexintong

Ziming Yuan

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Abstract

Objective To explore the formulation and dissolution of sustained-release tablets.Methods The formulation was optimized based on the orthogonal design L(34).The dissolution of puerarin was measured using the basket method as well as HPLC.Results In vitro release rate was more than 90% in 12h and there wasn't time-lag and sudden realease.Conclusion The quality of the sustained-release tabletsmeets China Pharmacopoeia(2005 version)criteria,and the formulation and the technics were feasible and steady-going.

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What this paper is about

Objective To explore the formulation and dissolution of sustained-release tablets.Methods The formulation was optimized based on the orthogonal design L(34).The dissolution of puerarin was measured using the basket method as well as HPLC.Results In vitro release rate was more than 90% in 12h and there wasn't time-lag and sudden realease.Conclusion The quality of the sustained-release tabletsmeets China Pharmacopoeia(2005 version)criteria,and the formulation and the technics were feasible and steady-going.

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Available abstract

Objective To explore the formulation and dissolution of sustained-release tablets.Methods The formulation was optimized based on the orthogonal design L(34).The dissolution of puerarin was measured using the basket method as well as HPLC.Results In vitro release rate was more than 90% in 12h and there wasn't time-lag and sudden realease.Conclusion The quality of the sustained-release tabletsmeets China Pharmacopoeia(2005 version)criteria,and the formulation and the technics were feasible and steady-going.

Key concepts: Dissolution, Chromatography, Puerarin, Pharmacopoeia, Lag time, Medical prescription, Chemistry, Dissolution testing

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