Study on platelet activation and platelet parameters in patients with cerebral infarction

Objective To investigate the changes and clinical significance of platelet membrane glucoprotein P-selection(CD_(62P)),lysosome membrance protein(CD_(63)) expression and three parameters of platelet in patients with cerebral infarction.Methods Peripheral blood platelet activation markers-CD_(62P),CD_(63) expression and three parameters-platelet count(PLT),mean platelet volume(MPV) and maximum platelet aggregation rate(MAR) were analyzed by flow cytometry and automatic blood analyzer in 168 patients with cerebral infarction and compared with 40 normal controls.Results(1) The positive rates of CD_(62P),CD_(63) and the levels of MPV,MAR in patients with cerebral infarction(both in acute phase and in convalescence) were significantly higher than those in normal controls(P 0.01),but there were no significant differences in PLT among these groups(P 0.05).The positive rate of CD_(62P),CD_(63) and the levels of MPV,MAR in acute phase were higher than those in convalescence after ischemic stroke(P 0.01).(2) There was a significant correlation among the levels of CD_(62P),CD_(63),MPV, MAR and the neurological functional deficit scale(r=0.84,r=0.817,r=0.684,r=0.698,P(0.01)),but there was no relation between PLT and the neurological functional deficit scale(r=0.32,P0.05).Conclusion Patients with cerebral infarction show evidence of enhanced platelet activation and increament of MPV and MAR,which may relate to the pathological process of cerebral infarction.Moreover MPV and MAR reflect the clinical severity of cerebral infarction better than PLT.