Changes blood-platelet parameters and functions in patients with silent cerebral infarction

Objective To explore the changes of blood-platelet parameters and functions in patients with silent cerebral infarction (SCI). Methods The levels of platelet count (PLT),mean platelet volume (MPV),platelet distribution width (PDW),and platelet-large cell ratio (P-LCR) were analyzed with automatic blood cell counter in 47 cases of patients with SCI and 47 cases of control group. Platelet maximum aggregation rate was detected by different inducer. The contents of plasma TXB2 and 6-keto-PGF1α were measured by ELISA. Results The MPV,PDW,and P-LCR in patients with SCI were higher than those of control group (P0.001),and there was no significant difference between the two groups in PLT (P0.05). The platelet maximum aggregation rate in patients with SCI was significantly higher than that of control group (P0.001). The level of plasma TXB2 in SCI group was significantly higher than that of control group (P0.001),but the level of plasma 6-keto-PGF1α in SCI group was markedly lower than that of control group (P0.001). Conclusions Changes of blood platelet parameters and the enhanced function of platelet are risk factors of SCI. Detection of platelet parameters and platelet functions has important significance for prevention SCI developing into symptomatic cerebral infarcion.