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HPLC fingerprint of coptis-evodia couplet medicines

Zhuang Yu-jian

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Abstract

AIM:The HPLC fingerprint of coptis-evodia couplet medicines was carried out to illustrate the effect of the compatibility to chemical compounds and to explain the mechenism of this compatibility.METHODS:The chromatographic fingerprints were obtained by measuring the coptis-evodia couplet medicine on an Agilent Zorbax extend-C18 column(4.6 mm × 250 mm,5 μm) with the gradient elution solvent system of acetonitrile-0.3% phosphoric 0.2% triethylamine-water.The flow rate was 0.7 mL/min,the column temperature was maintained at 20℃ and the detection wavelength was set at 268 nm.RESULTS:Nineteen co-possessing peaks were selected as the fingerprint peaks and preliminary assignment was also performed by taking berberine peak as the reference peak.CONCLUSION:From the couplet medicines angle,adding coptis into evodia in stew proves beneficial to the stripping of liposoluble alkaloids come from evodia in proportion.

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AIM:The HPLC fingerprint of coptis-evodia couplet medicines was carried out to illustrate the effect of the compatibility to chemical compounds and to explain the mechenism of this compatibility.METHODS:The chromatographic fingerprints were obtained by measuring the coptis-evodia couplet medicine on an Agilent Zorbax extend-C18 column(4.6 mm × 250 mm,5 μm) with the gradient elution solvent system of acetonitrile-0.3% phosphoric 0.2% triethylamine-water.The flow rate was 0.7 mL/min,the column temperature was maintained at 20℃ and the detection wavelength was set at 268 nm.RESULTS:Nineteen co-possessing peaks were selected as the fingerprint peaks and preliminary assignment was also performed by taking berberine peak as the reference peak.CONCLUSION:From the couplet medicines angle,adding coptis into evodia in stew proves beneficial to the stripping of liposoluble alkaloids come from evodia in proportion.

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Available abstract

AIM:The HPLC fingerprint of coptis-evodia couplet medicines was carried out to illustrate the effect of the compatibility to chemical compounds and to explain the mechenism of this compatibility.METHODS:The chromatographic fingerprints were obtained by measuring the coptis-evodia couplet medicine on an Agilent Zorbax extend-C18 column(4.6 mm × 250 mm,5 μm) with the gradient elution solvent system of acetonitrile-0.3% phosphoric 0.2% triethylamine-water.The flow rate was 0.7 mL/min,the column temperature was maintained at 20℃ and the detection wavelength was set at 268 nm.RESULTS:Nineteen co-possessing peaks were selected as the fingerprint peaks and preliminary assignment was also performed by taking berberine peak as the reference peak.CONCLUSION:From the couplet medicines angle,adding coptis into evodia in stew proves beneficial to the stripping of liposoluble alkaloids come from evodia in proportion.

Key concepts: Coptis, Chromatography, Chemistry, Couplet, High-performance liquid chromatography, Gradient elution, Medicine, Traditional Chinese medicine

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