Expression and clinical significance of S-100 protein and PCNA antigen in gastric carcinoma

Objective To study the clinical significance and effects of the expression of S-100~+dendritic cells(S-100~+DC) and proliferating cell nuclear antigen(PCNA) in the occurrence and development of gastric carcinoma. Methods S-100~+DC and PCNA expression was detected in 43 specimens of gastric carcinoma,24 cases of normal gastric mucosa using immunohistochemistry. Results The expression of S-100~+DC and PCNA in gastric carcinoma was markly higher than in normal gastric mucosa (P0.05). The number of S-100~+DC in the gastric carcinoma tissues withlow differentiation, lymph node and distant metastasis was significantly lower (P0.01). The positive rates of PCNA were correlated with lymph node metastasis, diatant metastasis, degree of differentiation, tumor size (P0.05),and no relation with depth of invasion and clinical stage(P0.05). A negative relationship was found between S-100~+DC and PCNA expressions in gastric cancer. Conclusion The change of S-100~+DC and HLA-DR in gastric mucosa were closely correlated with the clinical pathological parameters of gastric carcinoma. S-100~+DC in gastric cancer might play a role in inhibiting the growth of tumor cells and anti-tumor metastasis.