Expression and clinical significance of p53 and proliferating cell nuclear antigen (PCNA) in gastric carcinoma

Objective To study the relationgship among the expressions of p53 proteins and PCNA in gastric carcinoma and clinicopath-ological features and prognosis. Methods The expressions of p53 proteins and PCNA were detected in 33 cases of gastric carcinoma and 20 cases of normal gastric tissues by S-P immunohistochemistry. Results The postitive rates of p53 proteins and PCNA waa 57.6% and 93. 9%, respectively. The strongly positive rate of PCNA was 67.7%. The positive rate of p53 proteins and the strongly poaivtive rate of PCNA were correlated with histological type, depth of invasion and lymph node metastasis of gastric carcinoma. The difference was significant ( P 0.05). The expression of pS3 proteins was in positive relationship with the strongly positive rate of PCNA. Conclusions The detection of p53 proteins and PCNA is valuable for evaluating the malignancy degree, depth of invasion and lymph node mestastasis of gastric carcinoma and prognosis.