Distribution and drug resistance of common pathogens causing lower respiratory tract infection in children

OBJECTIVE To investigate the distribution and antibiotic resistance of pathogens isolated from sputum of children with lower respiratory tract infection for rational antibiotics therapy.METHODS A retrospective analysis for the distribution and antibiotic resistance of pathogens isolated from sputum of children with lower respiratory tract infection was made from Jan 2007 to Dec 2009.RESULTS Totally 945 strains were isolated,of which there were 566 strains of gram-negative bacilli,accounting for 59.89%,238 strains of gram-positive cocci,accounting for 25.19% and 141 strains of fungi,accounting for 14.92%.Imipenem and cefoperazone/sulbactam were most sensitive against gram-negative bacilli,while vancomycin and teicoplanin were most sensitive against gram-positive cocci.CONCLUSION gram-negative bacilli are the major pathogens in children with lower respiratory tract infection.Antibiotic resistance becomes more prevalent in some major pathogens.Rational use of antibiotics is important to reduce bacterial resistance.