Analysis of pathogens distribution and drug resistance in lower respiratory tract infection

Objective To analyze the pathogens distribution and antibiotic resistance in the patients with lower respiratory tract infection for rational antimicrobial theraphy.Methods Bacteria culture and drug sensitivity test of sputum samples of patients with lower respiratory tract infection from January 2011 to December 2011 in our hospital were analyzed retrospectively.Results Totally 336 pathogenic bacteria were separated,it included 185(55.1%) strains of Gram-negative bacilli,78(23.2%) strains of Gram-positive bacteria and 73(21.7%) strains of fungi.The most predominant Gram-negative bacteria isolates in order of frequency were P.aeruginosa,Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii.The resistance rates of Gram-negative bacteria to the commonly used antibiotics were very high.Imipenem,cefoperazone/sulbactam and piperacillin/tazobactam were effective antibiotics for treating Gram-negative bacteria infection.Staphylococcus aureus and Streptococcus pneumoniae were the main gram-positive cocci,and the resistance rates of them to the commonly used antibiotics were also high.No strains of gram-positive cocci isolated were resistant to vancomycin.Conclusion Gram-negative bacilli are main pathogens in lower respiratory tract infection and the antibiotic resistance grows more prevalent in some main pathogen strains.It is very important to emphasize pathogenic bacterium monitoring and pay attention to supervising drug resistance.