Effect of modified major bupleurum decoction on endotoxemia in rats with obstructive jaundice

Objective:To investigate the effect of modified major bupleurum decoction on liver function,lipid peroxidation and endotoxemia in rats with obstructive jaundice.Methods:Ninety SD rats were randomly divided into 3 groups:sham operation(SO)group( n =30),common bile duct ligation plus normal saline (BDL+NS)group( n =30),and common bile duct ligation plus major bupleurum decoction(BDL+MBD)group( n =30);acute obstructive jaundice models were established in the latter two groups.The rats were sacrificed on days 7,14 and 21,and the contents of MDA and endotoxin were determined.Results:MDA level in BDL+MBD group was higher than that in SO group( P 0.01)and lower than that in BDL+NS group( P 0.01)at 3 time points.Endotoxin concentrations of portal vein in BDL+NS group were superior to those in the other two groups ( P 0.01)at each time point.Conclusion:Modified major bupleurum decoction could have the protection of liver function and alleviation of endotoxemia.