Clinical study on the efficacy of phentolamine in treatment of intrahepatic cholestasis of pregnancy(ICP).

Objective:To investigate the efficacy and safety of Phentolamine in the treatment of the patients with ICP.Methods:60 primiparas with singleton ICP,32~36 gestational weeks,excluding pregnancy complications,medical and surgical illness,were enrolled.All patients were randomly divided into the control group and the study group,30 cases each.The control group were treated with dexamethasone,luminal and chinese traditional medicine,based on the treatment of the control group,Phentolamine was added to the study group.Observing the differences of itching and serum liver functional indexes between the before and after treatment;Compared with amniotic fluid meconium′s and neotatal asphyxia′s incidences and the results of umbilical cord arterial blood gas analysis in two groups;Supervise the blood pressures and heart rates in the coure of using Phentolamine.Results:(1) The differences of skin pruritus score and serum total bilirubin(TBIL),direct bilirubin(DBIL),total bile acid(TBA),cholyglycine(CG) between the before and after treatment were 1.48±0.71,8.65±5.32μmol/L,5.33±2.56μmol/L,27.65±13.45μmol/L,51.56±25.78μg/L,respectively;Whereas those in control group were 0.71±0.60,5.37±3.70μmol/L,2.99±2.0μmol/L,19.89±10.34μmol/L,35.25±20.35μg/L,respectively;There were significant differences between two groups(P0.05).There were no significant differences between two groups′ serum ALT and AST differences(P0.05).(2) Amniotic fluid meconium′s incidence,neotatal asphyxia′s incidence,pH value,PO2 and PCO2 of umbilical cord arteria blood in the study group were 7.14%,3.57%,7.26±0.07,24.86±11.20mmHg,43.34±10.41mmHg,respectively,Those in the control group were 32.14%,28.57%,7.22±0.04,19.25±6.90 mmHg,49.92±6.83 mmHg respectively,There were significant differences between two groups(P0.05).Cases of umbilical cord arterial blood pH7.2 in the study group and control group were 2 cases(7.14%),8 cases(28.57%),respectively,There were significant differences between two groups(P0.05).There were no significant differences among the blood pressures and heart rates during the using Phentolamine,the before and the after(P0.05).Conclusion:It′s safe and effective to treat ICP with Phentolamine which isn′t harmful to pregnant women.