Analysis on the efficacy of the combination of TCM and Western Medicine in treating intrahepatic cholestasis of pregnancy with different degree

Objective:To study the efficacy of the combination of TCM and Western Medicine in treating intrahepatic cholestasis of pregnancy with different degree.Methods:240 patients were randomly divided into two groups: A group(n=120) and B group(n=120).In A group,TCM YCT and western medicine(Transmetic,Dexamethasone,and Energy Mixture) were together used for the mild ICP,while TCM YDT and Western Medicine were together used for the severe ICP.In B group only Western Medicine was used for whichever mild ICP or severe ICP.60 patients of non-treatment were C group because of delivering within 3 days after hospitalization.The itch score,type-B ultrasonic efficacy,serum biochemical indexes,including TBA,ALT,and TBIL were observed before the treatment and after 2 weeks treatment,and the prognosis of perinatal newborn babies between the three groups was compared after delivery.Results:(1)The itch score,serum biochemical indexes of group A decreased significantly lower than those of group B(P0.05 or P0.01).(2)According to the type-B ultrasonic sonogram,the total effective power of group A was 95.83%,which was significantly higher than that of group B(85.00%)(P0.01).(3)The premature delivery rate,fetal distress rate and amniotic fluid pollution rate of mild ICP in group A were 16.5%,12.9%,and 12.9%,which were significantly lower than those of group B(23.5%,32.9%,17.6%) and group C(45.7%,50%,43.5%)(P0.01),but the perinatal babies mortality was no-significant among three groups.The premature delivery rate,fetal distress rate amniotic fluid pollution rate and perinatal babies mortality of severe ICP in group A were 20%,28.6%,25.7% and 2.9%,which were significantly lower than those of group B(31.4%,45.7%,42.9%,5.7%) and group C(64.3%,42.9%,71.4%,28.6%)(P0.05).Conclusion:The combination of TCM and Western Medicine for the different degree ICP is effective and reasonable treatment.