Observation on Clinical Curative Effect of Intrahepatic Cholestasis of Pregnancy with Combination of Traditional Chinese and Western Medicine

Objective :To study the clinical index and perinatal outcome of the treatment combined with traditional Chinese and Western medicine of intrahepatic cholestasis of pregnancy(ICP).Methods :168 pregnant women diagnosed as ICP were prospectively studied from October 2011 to February 2013 at Suzhou Hospital of Traditional Chinses Medicine.Patients with ICP were randomly divided into two groups :treated with traditional Chinese medicine decoction combined with Western medicine(ursodeoxycholic acid)in 88 cases for study group;and the other was treated with single ursodeoxycholic acid in 80 cases for control group.Comparison of the biochemical index between two groups before and after treatment :glycocholic acid(CG),total bile acid(TBA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(T-BIL)level changes and perinatal outcome were observed.Results :①Biochemical index in the study group after treatment was significantly improved than that of the control group,CG[(4.7±3.6)μmol/L vs(35.1±27.5)μmol/L],ALT[(23.5±14.5)U/L vs(96.1±20.7)U/L)],AST[(24.7±14.3)U/L vs(90.5±19.8)U/L],TBA[(4.6±3.5)μmol/L vs(7.8±4.9)μmol/L],T-BIL[(7.7±4.6)μmol/L vs(15.7± 10.6)μmol/L],D-BIL[(4.4±2.3) μmol/L vs(12.5±7.8)μmol/L],P0.05.The average gestational week of termination of pregnancy was significantly prolonged in study group than that in control group([38.1±1.5) weeks vs(35.6±1.7)weeks].The premature birth rates were 7.9% vs 23.8%,P0.05.② In study group,fetal distress(9.1% vs 26.3%),meconium stained amniotic fluid(18.8% vs 41.3%),neonatal asphyxia(0%vs 5%),the rate of cesarean section(29.5% vs 53.8%)and postpartum hemorrhage(2.3% vs 7.5%),were significantly lower than that of the control group. There was a significant difference between two groups,P0.05. Conclusion :It is suggested that the traditional Chinese medicine decoction combined with Western medicine could significantly prolong the gestational week,reduce the cesarean section rate and improve the perinatal outcome as compared with single Western medicine in patients with ICP.