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Expression levels and significance of C-erbB-2,ER and PR in patients with invasive breast ductal carcinoma

Xi Zhang

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Abstract

Objective:To explore the expression levels and correlation of estrogen receptor(ER),progestogen receptor(PR) and C-erbB-2 in patients with invasive breast ductal carcinoma.Methods:The expression levels of ER,PR and C-erbB-2 in 60 patients with invasive breast ductal carcinoma were detected by immunohistochemical method.Results:The positive expression rates of ER,PR and C-erbB-2 were 58.3 %(35/60),41.7 %(25/60) and 40.0%(24/60),respectively.There was significant difference between ER and PR(P0.05).There was no significant difference between ER and C-erbB-2(P0.05).There was no significant difference between PR and C-erbB-2(P0.05).Conclusion:C-erbB-2,ER and PR are possibly independent factors of prognosis of breast carcinoma,but the relationship between C-erbB-2 expression and ER,PR needs more researches,there is correlation between ER expression and PR expression in breast carcinoma.

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Objective:To explore the expression levels and correlation of estrogen receptor(ER),progestogen receptor(PR) and C-erbB-2 in patients with invasive breast ductal carcinoma.Methods:The expression levels of ER,PR and C-erbB-2 in 60 patients with invasive breast ductal carcinoma were detected by immunohistochemical method.Results:The positive expression rates of ER,PR and C-erbB-2 were 58.3 %(35/60),41.7 %(25/60) and 40.0%(24/60),respectively.There was significant difference between ER and PR(P0.05).There was no significant difference between ER and C-erbB-2(P0.05).There was no significant difference between PR and C-erbB-2(P0.05).Conclusion:C-erbB-2,ER and PR are possibly independent factors of prognosis of breast carcinoma,but the relationship between C-erbB-2 expression and ER,PR needs more researches,there is correlation between ER expression and PR expression in breast carcinoma.

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Available abstract

Objective:To explore the expression levels and correlation of estrogen receptor(ER),progestogen receptor(PR) and C-erbB-2 in patients with invasive breast ductal carcinoma.Methods:The expression levels of ER,PR and C-erbB-2 in 60 patients with invasive breast ductal carcinoma were detected by immunohistochemical method.Results:The positive expression rates of ER,PR and C-erbB-2 were 58.3 %(35/60),41.7 %(25/60) and 40.0%(24/60),respectively.There was significant difference between ER and PR(P0.05).There was no significant difference between ER and C-erbB-2(P0.05).There was no significant difference between PR and C-erbB-2(P0.05).Conclusion:C-erbB-2,ER and PR are possibly independent factors of prognosis of breast carcinoma,but the relationship between C-erbB-2 expression and ER,PR needs more researches,there is correlation between ER expression and PR expression in breast carcinoma.

Key concepts: Medicine, Estrogen receptor, Immunohistochemistry, Invasive ductal carcinoma, Ductal carcinoma, Breast carcinoma, Progestogen, Oncology

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Expression levels and significance of C-erbB-2,ER and PR in patients with invasive breast ductal carcinoma — Research Paper | ScholarLens