2012•Journal of Taishan Medical CollegeRequires access
Correlation analysis of chromosome in patients with acute leukemia
Shujing Du
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Abstract
Objective: To investigate value of cytogenetics in diagnosis and treatment of acute leukemia by chromosome analysis of acute leukemia and to analyze correlation between karyotype and prognosis according to cytogenetic classification standard.Methods: Chromosome of bone marrow cell was prepared by short-term culture method,karyotype of 77 acute leukemia patients was analyzed by G banding,and follow-up was done among the 63 patients received induction treatment.Results: In the 77 acute leukemia patients,detection rate of abnormal chromosome karyotype was 79%.And the first complete remission rate was 78% among the 63 patients that received treatment.Prognosis of patients with normal chromosome karyotype and typical t(15;17) was good.Conclusion: Over 70% acute leukemia patients have abnormal chromosome.Change of cytogenetics is an independent influence factor of prognosis in acute leukemia patients.