Cytogenetical analysis of 49 patients with acute leukemia

Objective To analyze the karyotype of the patient with acute leukemia,and investigate the value of cytogenetic examination in diagnosis and treatment of acute leukemia.Methods Cytogenetic examination of bone marrow cells was performed by short-turn culture method.G banding technique was used for karyotype analysis.30 patients accepted combined chemotherapy.Their response and survival rate were analyzed.Results Cytogenetical abnormalities were found in 36 of 49 acute leukemia cases.The total rate of chromosomal abnormality was 73%.In all the 30 cases accepted chemotherapy,the complete remission rate was 63%(19/30).Patients with normal karyotype and typical t(15;17) showed a better response to chemotherapy than cases with aberrant karyotype such as t(9;22) and t(5;17) etc.Conclusion Abnormal karyotype can be found in more than half of the acute leukemia cases.Some recurrent genetic abnormalities are usually associated with specifical type of leukemia.Genetic abnormality is a factor influences the treatment response of acute leukemia.