Comparative study between propafenone and sotalol in the treatment of persistent atrial fibrillation

Objective To compare the effect of propafenone and sotalol on persistent atrial fibrillation. Methods 50 patients with persistent atrial fibrillation were collected from January 2011 to March 2013 in our hospital,all the patients were randomly divided into sotalol group and propafenone group by random number table of the SAS analysis system. The cardioversion success rate,cardioversion,hospitalization time and recurrence rate,left atrial diameter, left ventricular ejection fraction,heart rate,QT interval and adverse reactions were compared between the two groups. Results The success rate of propafenone group was significantly higher than that of sotalol group(P 0. 05),the cardioversion and hospital stay were significantly shorter than those of sotalol group( P 0. 05),there was no significant difference in the recurrence rate between the two groups( P 0. 05). After treatment,no obvious difference was observed in left ventricular diameter and left ventricular ejection fraction( P 0. 05),but the heart rate decreased( P 0. 05),and QT interval was significantly longer( P 0. 05). There was no significant difference in left ventricular diameter,left ventricular ejection fraction,heart rate,QT interval between the two groups( P 0. 05). There were 8 cases and 7 cases of adverse reactions in sotalol group and propafenone group,there was no significant difference between the two groups( P 0. 05). Conclusion Short-term large dose of propafenone has better effect on cardioversion success rate and cardioversion time of persistent atrial fibrillation patients compared with sotalol,it is an effective treatment method for persistent atrial fibrillation.