Clinical efficacy of low-dose Sotalol combined with Propafenone in patients with paroxysmal atrial fibrillatien

Objective To observe the clinical efficacy of low-dose sotalol combined with propafenone for paroxysmal atrial fibrillation(PAF).Methods 29 patients with PAF were divided into two groups:GroupⅠ,after sotalol treansformed PAF low-dose sotalol 80mg/d and propafenone 300mg/d maintained sinus rhythm;GooupⅡ,after amiodarone treansformed PAF amiodarone 0.2g/d or 0.2g/d,five days in every week maintained.The treatment lasted for three months.Times of atrial fibrillation and lasting time,sinus heart rate,Q—T interval and adverse reactions were observed in every week.Results In groupⅠ,groupⅡmarkedly effective rate were 69.23%,80% respectively;effective rate respectively were 30.77%,20%. There were no significant differences in the two groups (P＞0.05).Before and after treatment between two groups there were significant differences in sinus heart rate (all,P＜0.01).But there was no significant difference in sinus heart rate after the treatment between two groups(P＞0.05).There all were no signifcant difference in Q-T interval before and after treatment between the two groups(all,P＞0.05).Conclusion The clinical effects of low-dose sotalol combined with propafenone for PAF are better and relatively safe.The occurrence rates of adverse reaction are very low.