Observation on effect of combining drugs to treat severe preeclampsia

Objective To observe the clinical effects of drug combination therapy for severe preeclampsia.Methods 72 patients with severe preeclampsia admitted to the first affiliated hospital of Zhengzhou University from January 2010 to December 2012 were divided into two groups.The control group(37 cases) was treated by conventional methods,while the treatment group(35 cases) was treated by combination of low molecular heparin,Nimodipine and Danshen Injection on the basis of conventional methods.Before and after treatment,the mean arterial pressure changes in different period,urine volume and urine protein in 24 hours,convulsion frequency ratio changes of two groups were observed.Results After treatment for both groups,the mean arterial pressure of 12 and 24 hours had been significantly reduced,urine volume increased and urine protein decreased,with statistically significant differences(P 0.05) compared with those before treatment;in the treatment group,mean arterial pressure significantly reduced,urine volume increased and urine protein decreased,with statistically significant differences(P 0.05) compared with control group;the convulsion frequency ratio of treatment group in different period had been reduced with statistically significant differences(P 0.05) compared with that of control group.Conclusion Drug combination therapy has marked effect for severe preeclampsia,can better prevent and control the attack of preeclampsia.