Clinical Effect of Magnesium Sulfate Combined with Low Molecular Heparin in the Treatment of Patients with Severe Preeclampsia

Objective To explore the effect of magnesium sulfate combined with low molecular heparin in the treatment of patients with severe preeclampsia and influence on the expression of interleukin-4( IL-4)and interleukin-6( IL-6). Methods From Sep. 2010 to Jul. 2012,108 patients with severe preeclampsia from Longgang Maternal and Child Health Institute were divided randomly into two groups: the control group( n =54),treated with magnesium sulfate only,and the test group( n = 54),treated with magnesium sulfate combined with low molecular heparin. The blood pressure,prognosis of neonate and the expression of IL-4and IL-6 were compared between the two groups. Results After treatment,systolic,diastolic,and mean arterial pressure were lower,but systolic,diastolic and mean arterial blood pressure in the test group decreased more significantly than the control group,there were statistically significant difference( t = 4. 730,5. 242,4. 773,P 0. 01); after treatment,IL-4 and IL-6 levels were reduced,but serum IL-4,IL-6 levels in the test group decreased more significantly than control group,there were statistically significant difference( t = 11. 846,22. 830,P 0. 05). The percentage of Apagr score 7 was 14. 81%( 8 /54) in the test group,lower than40. 74%( 19 /54),of the control group( χ2= 5. 98,P 0. 05). Conclusion Effect of magnesium sulfate combined with low molecular heparin in the treatment of patients with severe preeclampsia is significant,which could reduce the blood pressure,improve the prognosis of neonate and has a certain anti-inflammatory effect.