Clinical research on the impact of perdipine to cure early onset severe preeclampsia

Objective To explore the impact of perdipine to haemodynamics and the concentration with serum Ca2+,Mg2+ in the early onset severe preeclampsia.MethodsEarly onset severe preeclampsia were randomly divided into two groups: group A(perdipine treatment group) of 66 cases;Group B(phentolamine treatment group) of 67 cases.Testing before and after treatment in blood pressure,serum Ca2+,Mg2+ concentration and protein in urine changing,and so on.Results①Changes in blood pressure: systolic blood pressure and diastolic blood pressure decrease before and after treatment in each group,mainly in systolic blood pressure decreased,the decline of group A was particularly significant,group A with significant differences compared with group B(P0.05).Group A reach the level of effect after 3 days,while group B after treatment for 4 days.Group B had found 2 cases of resistant hypertension patients,the incidence rate of 2.99 percent.②Serum Ca2+,Mg2+ concentration changes: in each group after treatment serum Ca2+,Mg2+ concentration have increased,the difference between before and after treatment was significantly(P0.05);and the control group with no significant difference(P0.05).③Compared urinary protein declined: total volume urine protein decrease in each group,before and after therapy the two group had statistical significance(P0.05),the control group with no significant group difference(P0.05).④Pregnancy outcome: the average gestation time of group A was significantly increased than that in group B(P0.05),and fetal Apgar score group A was better than group B,two groups of postpartum hemorrhage,birth weight had no significant difference.ConclusionPerdipine with magnesium sulfate not only has affirmative curative effect in the treatment of early onset severe preeclampsia,but also has some effect on resistant hypertension.It is deserved to be applied.