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2001•Journal of Qilu OncologyRequires access

Study of Point Mutations in the p53 Gene of Laryneal Cancer

Zhao Shu

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Abstract

Objective To study point mutations in the p53 gene of laryngeal neoplasms.Methods PCR RFLP.Results The mutation ratio of 205 codon in the exon 6 of p53 gene of laryngeal neoplasms is 13.5%.The mutation condition has no relation with differention.The mutation ratio of 248 codon in the exon 7 of p53 gene is 0.Conclusion The 205 codon of p53 gene is a hot spot of laryngeal neoplasms.

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What this paper is about

Objective To study point mutations in the p53 gene of laryngeal neoplasms.Methods PCR RFLP.Results The mutation ratio of 205 codon in the exon 6 of p53 gene of laryngeal neoplasms is 13.5%.The mutation condition has no relation with differention.The mutation ratio of 248 codon in the exon 7 of p53 gene is 0.Conclusion The 205 codon of p53 gene is a hot spot of laryngeal neoplasms.

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Available abstract

Objective To study point mutations in the p53 gene of laryngeal neoplasms.Methods PCR RFLP.Results The mutation ratio of 205 codon in the exon 6 of p53 gene of laryngeal neoplasms is 13.5%.The mutation condition has no relation with differention.The mutation ratio of 248 codon in the exon 7 of p53 gene is 0.Conclusion The 205 codon of p53 gene is a hot spot of laryngeal neoplasms.

Key concepts: Exon, Point mutation, Gene, Mutation, Gene mutation, Genetics, Biology, Laryngeal Neoplasm

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