Efficacy Observation of Reduced Glutathione in the Treatment of Chemotherapeutics-induced Liver Lesion Caused by Chemotherapy in Cancer Patients

OBJECTIVE:To observe clinical efficacy of reduced glutathione in the treatment of chemotherapeutics-induced liver lesion in cancer patients.METHODS:85 patients with drug-induced liver lesion after chemotherapy were randomly divided into 2 groups.Treatment group were treated with reduced glutathione and diammonium glycyrrhizinate injection (n=43) and control group were treated with diammonium glycyrrhizinate (n=42).Clinical efficacies of 2 groups were compared.RESULTS:After 2 weeks,average value of several index in treatment group were lower than in control group,there were significant difference between 2 groups (P0.05).Clinical symptom and liver function of treatment group were improved significantly.Total response rate were 95.3% for treatment group and 78.6% for control group,there were significant difference between 2 groups (P0.05).CONCLUSION:Reduced glutathione is effective in the treatment of chemotherapeutics-induced liver lesion in patients with malignant tumors.