Correlative study of angiogenesis with the CT multi-phase scan features of benign prostatic hyperplasia and prostate cancer

Objective:Based on investigating the relationship between microvascular density(MVD),related indexes of microvascular,basic fibroblast growth factor(bFGF)and the clinicopathologic characters in benign prostatic hyperplasia(BPH)and prostate cancer(PCa),to explore the correlation between the features of multi-slice spiral computed tomography(MSCT)and the level of MVD,bFGF and related indexs of microvascular in BPH and PCa.Methods:Thirty-five BPH and twenty-seven PCa cases proved by histopathology were examined with multi-phase contrast-enhanced MSCT scanning.The time-density curve(T-DC)and slope(S)of the contrast media uptake curve were recorded.Immunohistochemical technique of all specimens was performed.Results:Time-density curves were classified to three groups,the difference between BPH and PCa in the type of the curves was observed(P0.01).The number of MVD in BPH and PCa were 11.00±4.14 and 32.11±13.19,respectively.The related indexes of microvascular of BPH such as diameter were bigger than those of PCa(P0.01).The level of bFGF in PCa was higher than in BPH(P0.01).There were significant positive correlation between bFGF and MVD(P0.01),and between the slope(S)and MVD,bFGF(P0.05).The slope(S)was correlated positively with Gleason grade and differentiation of PCa(P0.05).There was positive correlation between MVD and Gleason grade,differentiation of the tumor(P0.01).Conclusion:The level of bFGF and MVD in PCa was higher than that of in BPH.MSCT can display the blood supply and enhancement characters of BPH and PCa.The MSCT imaging of BPH and PCa can reflect the expression of angiogenesis factor and angiogenesis.