Correlative study of the expression of VEGF and MVD with the MSCT multi-phase scan features in benign prostatic hyperplasia and prostate cancer

Objective:To investigate the expression of microvascular density(MVD) and vascular endothelial growth factor(VEGF) in benign prostatic hyperplasia(BPH) and prostate cancer;To study the relationship between the contrast-enhanced features of multi-slice spiral computed tomography(MSCT) and the angiogenesis and some clinicopathologic characteristics of BPH and prostate cancer.Materials and Methods:Twenty-five BPH and fifteen prostate cancer cases proved by histopathology were examined with multi-phase contrast-enhanced MSCT scanning before operation or biopsy.The results of MSCT were evaluated by peak value(PV) and maximum attenuation value(MAV) and time-density curve(T-DC).Hematoxylin and eosin staining and S-P immunohistochemical technique were experimented on all paraffin sections,VEGF and MVD measurements were performed.The relationships among MSCT findings,VEGF,MVD and clinicopathologic features were analyzed.Results:PV in prostate cancer was found earlier than in BPH,there was significant difference between them(P0.01).The types of T-DC in the group of BPH were mainly found as type I(20/25),but in the group of prostate cancer were mainly found as type II and type III(11/15).The difference proved significantly(P0.01).The MAV of BPH and prostate cancer was(42.00±10.99)HU and(45.60±6.88)HU respectively,no difference was found between them(P0.05).The expression of VEGF,MVD in PCa were significantly higher than in BPH(P0.05,P0.001).In BPH and prostate cancer,there was significant correlation between VEGF and MVD(P0.01,P0.05) and between MVD and MAV(P0.05,P0.05).In prostate cancer,there were statistical correlation between MVD and Gleason grade,clinic stage(P0.05) and between VEGF and the differentiation of the tumor and Gleason grade(P0.05).Conclusion:Prostate cancer is a tumor rich in blood supply.MSCT scanning can reflect the blood supply and enhancement characters and the angiogenesis of BPH and prostate cancer,it has significant importance in detection and diagnosis of the prostate carcinoma lesions.