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2006•Letters in BiotechnologyRequires access

Biological Mass Spectrometry and its Application in Proteomics Research

Yueming Yan

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Abstract

Biological mass spectrometry,one of the key techniques in proteomics research,has improved greatly with higher throughput,higher sensitivity and higher resolution.Because of these improvements proteomics has experienced rapid advancement in recent years.This review focuses on the major points of the principle,the technique and the apparatus of biological mass spectrometry,and these improvements and the successful applications of biological mass spectrometry in proteomics research.

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What this paper is about

Biological mass spectrometry,one of the key techniques in proteomics research,has improved greatly with higher throughput,higher sensitivity and higher resolution.Because of these improvements proteomics has experienced rapid advancement in recent years.This review focuses on the major points of the principle,the technique and the apparatus of biological mass spectrometry,and these improvements and the successful applications of biological mass spectrometry in proteomics research.

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Available abstract

Biological mass spectrometry,one of the key techniques in proteomics research,has improved greatly with higher throughput,higher sensitivity and higher resolution.Because of these improvements proteomics has experienced rapid advancement in recent years.This review focuses on the major points of the principle,the technique and the apparatus of biological mass spectrometry,and these improvements and the successful applications of biological mass spectrometry in proteomics research.

Key concepts: Proteomics, Mass spectrometry, Chemistry, Bottom-up proteomics, Computational biology, Chromatography, Tandem mass spectrometry, Protein mass spectrometry

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