Application of mass spectrometry in proteomics studies

With the rapid development of proteomics,mass spectrometry is maturing to be a powerful tool and core technology for proteomics studies during the recent years.The superiority of mass spectrometry lies in providing the throughput and the molecular information,which no other technology can be matched in proteomics.In this review,we made a glance on the outline of mass spectrometry-based proteomics.And then we addressed on the advances of data analysis of mass spectrometry-based proteomics,quantitative mass spectrometry-based proteomics,post-translational modifications based mass spectrometry,targeted proteomics and functional proteomics based-mass spectrometry.