The efficacy and safety clinical analysis of paroxetine on the 90 post-stroke depression patients

Objective To investigate the clinical efficacy and safety of paroxetine on the post-stroke depression patients.Methods 90 cases with post-stroke depression were randomly divided into treatment group and control group,45 cases differently.The treatment group was treated with paroxetine and conventional cerebrovascular medicine.The control group was given conventional cerebrovascular medicine only.The efficacy and adverse events were assessed by HAMD,NIHSS,BI and TESS before and after treatment 1,4,8 weeks,respectively.Results Comparing the treatment group before and after,HAMD at week 4(F = 10.47,P = 0.019),at week 8(F = 56.64,P 0.001);NIHSS at week 4(F = 16.23,P = 0.037),at week 8(F = 24.52,P = 0.011).Barthel at week 4(F = 15.64,P = 0.032),at week 8(F = 27.12,P = 0.009).TESS was no significant difference on the rate of adverse events between the two groups(4.3 ± 1.7,4.2 ± 1.6,P 0.05).Conclusion Paroxetine was effective and safe antidepressant on the post-stroke depression patients.