The predictive value of serum levels of IL-6, CRP and PCT in patients with MODS after severe multiple trauma

Objective To investigate the predictive value of serum levels of interleukin-6(IL-6), C reactive protein(CRP) and procalcitonin(PCT) in patients with multiple organ dysfunction syndrome(MODS) after severe multiple trauma. Methods A total of 87 patients with multiple trauma were divided into MODS and non-MODS groups. The peripheral serum concentrations of IL-6 and PCT were detected by enzyme-linked immunosorbent assay at 1, 2, 3, 5 and 7d after severe multiple trauma, while CRP level was detected by immunoturbidimetry. All data were managed by receiver operating characteristic(ROC). Results Compared with healthy control group, serum levels of IL-6, CRP and PCT in patients with multiple trauma were increased differently in early posttrauma period (P 0.01). The serum level of PCT elevated earlier than those of IL-6 and CRP. The levels of IL-6, CRP and PCT in MODS group were significantly higher than those in non-MODS group (P 0.01). Area under ROC curve of IL-6, CRP and PCT was 0.686, 0.854 and 0.914 respectively. PCT had more diagnostic value than IL-6 and CRP for diagnosis of MODS after severe multiple trauma. Conclusion The PCT is confirmed to be more sensitive and specific than IL-6 and CRP for diagnosis of MODS after severe multiple trauma.