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2012•Journal of Clinical Medicine in PracticeRequires access

Expression of microRNA-200a and its clinical significance in ovarian epithelial cancer

Peizhen Xu

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Abstract

Objective To investigate the expression and clinical significance of microRNA-200a in epithelial ovarian cancer.Methods The expressions of miR-200a in 40 epithelial ovarian cancer and 30 benign ovarian epithelial tumors were examined by stem-loop real-time RT-PCR.The correlations between the expression of miR-200a and clinicopathologic features(FIGO stage,pathological type,histological grading and lymphatic metastasis) were further analyzed.Results The expression of miR-200a was significantly higher in epithelial ovarian cancer than in benign ovarian epithelial tumors,but it was lower in advanced ovarian cancer than at early stage.Conclusion miR-200a may play a role as an oncogene in epithelial ovarian cancer,and is possibly correlated with the progression and metastasis at advanced stage.

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What this paper is about

Objective To investigate the expression and clinical significance of microRNA-200a in epithelial ovarian cancer.Methods The expressions of miR-200a in 40 epithelial ovarian cancer and 30 benign ovarian epithelial tumors were examined by stem-loop real-time RT-PCR.The correlations between the expression of miR-200a and clinicopathologic features(FIGO stage,pathological type,histological grading and lymphatic metastasis) were further analyzed.Results The expression of miR-200a was significantly higher in epithelial ovarian cancer than in benign ovarian epithelial tumors,but it was lower in advanced ovarian cancer than at early stage.Conclusion miR-200a may play a role as an oncogene in epithelial ovarian cancer,and is possibly correlated with the progression and metastasis at advanced stage.

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Available abstract

Objective To investigate the expression and clinical significance of microRNA-200a in epithelial ovarian cancer.Methods The expressions of miR-200a in 40 epithelial ovarian cancer and 30 benign ovarian epithelial tumors were examined by stem-loop real-time RT-PCR.The correlations between the expression of miR-200a and clinicopathologic features(FIGO stage,pathological type,histological grading and lymphatic metastasis) were further analyzed.Results The expression of miR-200a was significantly higher in epithelial ovarian cancer than in benign ovarian epithelial tumors,but it was lower in advanced ovarian cancer than at early stage.Conclusion miR-200a may play a role as an oncogene in epithelial ovarian cancer,and is possibly correlated with the progression and metastasis at advanced stage.

Key concepts: Medicine, Ovarian cancer, microRNA, Grading (engineering), Pathological, Stage (stratigraphy), Epithelial ovarian cancer, Metastasis

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