Therapeutic effect observations of pantoprazole combined with itopride for reflux esophagitis

Objective To investigate the clinical efficacy of the pantoprazole combined with itopride for reflux esophagitis.Methods A total of 208 patients with confirmed reflux esophagitis were equally randomized into treatment and control groups.The treatment group received pantoprazole combined with itopride,while the control group took ranitidine combined with itopride.The clinical symptoms and endoscopic changes in the two groups were observed before treatment,and 4 weeks and 8 weeks after treatment.Results The overall response rate and healing rate of endoscopic esophageal mucosal lesion were better in the treatment group than in the control group 4 and 8 weeks after treatment(P0.01).Conclusion The pantoprazole in combination with itopride for reflux esophagitis is safe,reliable and effective,superior to ranitidine combined with itopride,and worthy of wider application.