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Efficacy of itopride and omeprazole or famotidine in the treatment of reflux esophagitis

Peng Bo-jia

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Abstract

Objective To evaluate the efficacy of itopride and omeprazole or famotidine in the treatment of reflux esophagitis.Methods 82 patients were divided into 2 groups randomly:the observation group and control group,with 41 cases of each group.Patients in observation group were treated with omeprazole capsule 20 mg Bid and itopride 50 mg Tid,while patients in control group were treated with famotidine 20 mg Bid and itopride 50 mg Tid.The effects were appraised by observation of heartburn,backflow,chest pain and endoscopy after 8 weeks' treatment.Results The total efficiency of the omeprazole group was 100% by clinical observation and 95.1% by endoscopy,respectively,while the total efficiency of oamotidine group was 85.4% by clinical observation and 75.6% by endoscopy,respectively,and there was a significant difference between these two groups(P0.05).Conclusion Itopride and omeprazole is better than itopride and famotidine in the treatment of reflux esophagitis.

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What this paper is about

Objective To evaluate the efficacy of itopride and omeprazole or famotidine in the treatment of reflux esophagitis.Methods 82 patients were divided into 2 groups randomly:the observation group and control group,with 41 cases of each group.Patients in observation group were treated with omeprazole capsule 20 mg Bid and itopride 50 mg Tid,while patients in control group were treated with famotidine 20 mg Bid and itopride 50 mg Tid.The effects were appraised by observation of heartburn,backflow,chest pain and endoscopy after 8 weeks' treatment.Results The total efficiency of the omeprazole group was 100% by clinical observation and 95.1% by endoscopy,respectively,while the total efficiency of oamotidine group was 85.4% by clinical observation and 75.6% by endoscopy,respectively,and there was a significant difference between these two groups(P0.05).Conclusion Itopride and omeprazole is better than itopride and famotidine in the treatment of reflux esophagitis.

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Available abstract

Objective To evaluate the efficacy of itopride and omeprazole or famotidine in the treatment of reflux esophagitis.Methods 82 patients were divided into 2 groups randomly:the observation group and control group,with 41 cases of each group.Patients in observation group were treated with omeprazole capsule 20 mg Bid and itopride 50 mg Tid,while patients in control group were treated with famotidine 20 mg Bid and itopride 50 mg Tid.The effects were appraised by observation of heartburn,backflow,chest pain and endoscopy after 8 weeks' treatment.Results The total efficiency of the omeprazole group was 100% by clinical observation and 95.1% by endoscopy,respectively,while the total efficiency of oamotidine group was 85.4% by clinical observation and 75.6% by endoscopy,respectively,and there was a significant difference between these two groups(P0.05).Conclusion Itopride and omeprazole is better than itopride and famotidine in the treatment of reflux esophagitis.

Key concepts: Famotidine, Medicine, Omeprazole, Heartburn, Reflux esophagitis, Gastroenterology, Internal medicine, Endoscopy

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